Major issues related to frailty and aging

Among the various open questions raised by normal and pathological ageing, the Lc65+ cohort aims to contribute to answering the following:

Why do some individuals get frail but others remain robust until a very old age ?

What are the first manifestations of frailty? Can we detect frailty early ?

Is the frailty process perceived by older persons? Does frailty change their quality of life ?

Are there different ways to become frail? What parts do somatic and mental health disturbances play in the development of frailty ?

What factors influence the evolution of frailty and the development of its consequences? Are there modifiable factors that might help design interventions to prevent frailty and its consequences ?